The Ambivalence of Cytostatic Therapy
E. GRUNDMANN The question as to whether cytostatic drugs might be carcinogenic has been presented and discussed in three experimental studies. The most extensive in vestigations were by J. H. WEISBURGER and coll. (New York, Alabama, Bethesda). They started with an exact determination of rate and localization for spon- . taneous tumors in their animal strains. Thirteen cytostatic compounds current ly in clinical use were then given in the maximally tolerated dose (MTD) to groups of 25 male and 25 female animals (rats and mice) three times weekly, in most assays over a period of 6 months. Other identical groups of animals received 0. 5 of the…
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Produktdetails
Weitere Autoren: Grundmann, Ekkehard (Hrsg.)
- ISBN: 978-3-642-80942-2
- EAN: 9783642809422
- Produktnummer: 13393545
- Verlag: Springer Berlin Heidelberg
- Sprache: Englisch
- Erscheinungsjahr: 2012
- Seitenangabe: 260 S.
- Masse: H24.4 cm x B17.0 cm x D1.4 cm 455 g
- Auflage: Softcover reprint of the original 1st ed. 1975
- Abbildungen: Paperback
- Gewicht: 455
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