Current Topics in Microbiology and Immunology
Immunoglobulin gene expression appears to include a number of unique features (Cohn, 1971; Gaily and Edelman, 1972; Hood et aI. , 1975). First, a variety of genetic and protein structural evidence suggests that two discrete genes - both a variable region gene and a constant region gene - specify each heavy chain and each light chain. This constitutes the twogene-one polypeptide hypothesis. Second, a single differentiated lymphocyte or plasma cell appears to express only one heavy chain allele and one light chain allele at a time. This is the only example of allelic exclusion known in mammalian cells except for X chromosome inactivation. Third…
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Weitere Autoren: Henle, W. / Hofschneider, P. H. / Humphrey, J. H. / Klein, J. / Koldovský, P. / Koprowski, H. / Maaløe, O. / Melchers, F. / Rott, R. / Schweiger, H. G. / Syru?ek, L. / Vogt, P. K.
- ISBN: 978-3-642-66655-1
- EAN: 9783642666551
- Produktnummer: 13337030
- Verlag: Springer Berlin Heidelberg
- Sprache: Englisch
- Erscheinungsjahr: 2011
- Seitenangabe: 224 S.
- Masse: H24.4 cm x B17.0 cm x D1.2 cm 395 g
- Auflage: Softcover reprint of the original 1st ed. 1977
- Abbildungen: Paperback
- Gewicht: 395
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Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung
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