Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules
This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials - the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the…
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Produktdetails
- ISBN: 978-3-319-39025-3
- EAN: 9783319390253
- Produktnummer: 20068058
- Verlag: Springer-Verlag GmbH
- Sprache: Englisch
- Erscheinungsjahr: 2016
- Seitenangabe: 266 S.
- Plattform: PDF
- Masse: 22'882 KB
- Auflage: 1st ed. 2016
- Abbildungen: 356 schwarz-weiße und 11 farbige Abbildungen, Bibliographie
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