Early Drug Development
Bringing a Preclinical Candidate to the Clinic
This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues.After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final sec…
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Produktdetails
Weitere Autoren: Buschmann, Helmut (Reihe Hrsg.) / Holenz, Jörg (Reihe Hrsg.) / Giordanetto, Fabrizio (Hrsg.)
- ISBN: 978-3-527-80176-3
- EAN: 9783527801763
- Produktnummer: 27632548
- Verlag: Wiley-Vch
- Sprache: Englisch
- Erscheinungsjahr: 2018
- Seitenangabe: 816 S.
- Plattform: PDF
- Masse: 19'676 KB
Über den Autor
Fabrizio Giordanetto graduated in Medicinal Chemistry (Genoa, Italy) followed by his Ph.D. (London, UK) while working for the chemistry unit of Pharmacia - Pfizer (Italy). After positions at AstraZeneca (Sweden) as Principal Scientist and Project Leader and at Taros (Germany) as Head of Medicinal Chemistry, he has recently joined DE Shaw Research LLC (New York, USA) where he leads medicinal chemistry activities and drug discovery projects. During his career, he worked on several drug discovery programs resulting in multiple clinical candidates spanning oncology, CNS, inflammation, metabolic and cardiovascular indications and >100 international patents, peer-reviewed publications and book chapters.
100 weitere Werke von Raimund (Reihe Hrsg.) Mannhold:
Chemoinformatics in Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 242.00
Protein Crystallography in Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 170.00
Aspartic Acid Proteases as Therapeutic Targets
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 186.00
Protein Kinases as Drug Targets
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 156.00
G Protein-Coupled Receptors as Drug Targets
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 215.00
Proteomics in Drug Research
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 209.00
Molecular Descriptors for Chemoinformatics
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 425.00
Advanced Computer-Assisted Techniques in Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 151.00
Transporters as Drug Carriers
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 193.00
Chemogenomics in Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 220.00
Evolutionary Algorithms in Molecular Design
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 164.00
Data Mining in Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 153.00
Scaffold Hopping in Medicinal Chemistry
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 153.00
Phosphodiesterases and Their Inhibitors
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 131.00
Ligand Design for G Protein-coupled Receptors
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 200.00
Protein-Ligand Interactions
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 156.00
Microwaves in Organic and Medicinal Chemistry
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 198.00
Combinatorial Chemistry
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 182.00
Chemokine Receptors as Drug Targets
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 159.00
Protein-Ligand Interactions
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 156.00
Protein-Protein Interactions in Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 156.00
Drug Metabolism Prediction
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 164.00
Epigenetic Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 175.00
Epigenetic Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 195.00
Innovative Dosage Forms
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 195.00
Neglected Tropical Diseases
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 195.00
Target Discovery and Validation
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 175.00
Innovative Dosage Forms
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 195.00
Drug Metabolism Prediction
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 164.00
Solid State Development and Processing of Pharmaceutical Molecules
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 207.70
New Drug Development for Known and Emerging Viruses
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 429.00
Microwaves in Organic and Medicinal Chemistry
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 198.00
Pharmacophores and Pharmacophore Searches
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 193.00
Protein-Ligand Interactions
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 153.00
Fragment-based Approaches in Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 220.00
Pharmacokinetics and Metabolism in Drug Design
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 122.00
Bioisosteres in Medicinal Chemistry
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 137.00
Natural Products in Medicinal Chemistry
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 175.00
Medicinal Chemistry Approaches to Personalized Medicine
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 153.00
Bioisosteres in Medicinal Chemistry
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 137.00
Protein-Protein Interactions in Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 156.00
Phosphodiesterases and Their Inhibitors
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 131.00
In vivo Models for Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 164.00
Protein Therapeutics, 2 Volume Set
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 175.00
Protein Therapeutics, 2 Volume Set
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 175.00
Transporters as Drug Targets
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 164.00
Transporters as Drug Targets
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 164.00
Early Drug Development
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 308.00
Neglected Tropical Diseases
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 195.00
Fragment-based Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 164.00
Reactive Drug Metabolites
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 156.00
Quantum Medicinal Chemistry
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 170.00
Molecular Biology in Medicinal Chemistry
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 198.00
Antiviral Drug Strategies
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 159.00
Mass Spectrometry in Medicinal Chemistry
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 215.00
Molecular Interaction Fields
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 198.00
Prodrugs and Targeted Delivery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 164.00
Virtual Screening for Bioactive Molecules
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 164.00
Structure-based Ligand Design
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 153.00
Lipophilicity in Drug Action and Toxicology
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 127.00
Aspartic Acid Proteases as Therapeutic Targets
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 186.00
Solid State Development and Processing of Pharmaceutical Molecules
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 207.70
New Drug Development for Known and Emerging Viruses
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 386.00
Prodrugs and Targeted Delivery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 164.00
Nuclear Receptors as Drug Targets
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 215.00
Pharmacokinetics and Metabolism in Drug Design
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 137.00
Reactive Drug Metabolites
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 156.00
Data Mining in Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 153.00
Natural Products in Medicinal Chemistry
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 175.00
Scaffold Hopping in Medicinal Chemistry
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 153.00
Medicinal Chemistry Approaches to Personalized Medicine
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 153.00
Voltage-Gated Ion Channels as Drug Targets
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 215.00
Chemokine Receptors as Drug Targets
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 159.00
Combinatorial Chemistry
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 253.00
Chemometric Methods in Molecular Design
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 153.00
High-Throughput Screening in Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 198.00
Handbook of Molecular Descriptors
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 314.00
Drug-Membrane Interactions
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 142.00
In vivo Models for Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 164.00
Target Discovery and Validation
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 175.00
Thermodynamics and Kinetics of Drug Binding
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 164.00
BioNMR in Drug Research
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 198.00
Chirality in Drug Research
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 204.00
Antiviral Drug Strategies
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (EPUB Format)
CHF 159.00
Thermodynamics and Kinetics of Drug Binding
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 164.00
Protein Kinases as Drug Targets
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 156.00
Fragment-based Drug Discovery
Bringing a Preclinical Candidate to the Clinic
Bringing a Preclinical Candidate to the Clinic
Ebook (PDF Format)
CHF 164.00
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