Chemogenomics in Drug Discovery
A Medicinal Chemistry Perspective
Die Chemogenomik ist eine Brückendisziplin zwischen Chemie und Biologie, die im Rahmen der Suche nach neuen Wirkstoffen Ansätze der kombinatorischen Chemie mit Proteomik und Genomik verbindet. Zwanzig Forschungsgruppen von Universitäten und aus pharmazeutischen Unternehmen erläutern Ihnen in diesem Band alle Schritte der frühen Wirkstoffforschung - von der Wahl des Targets über Verbindungsbibliotheken bis zum Design von Leitstrukturen. Wirkstoffentwickler und medizinische Chemiker, die mit chemogenomischen Methoden arbeiten, werden auf diese umfangreiche und kompetente Informationsquelle nicht verzichten wollen.
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Produktdetails
Weitere Autoren: Folkers, Gerd (Reihe Hrsg.) / Müller, Gerhard (Hrsg.) / Kubinyi, Hugo (Hrsg.)
- ISBN: 978-3-527-60402-9
- EAN: 9783527604029
- Produktnummer: 13850595
- Verlag: Wiley-Vch
- Sprache: Englisch
- Erscheinungsjahr: 2006
- Seitenangabe: 487 S.
- Plattform: PDF
- Masse: 7'051 KB
Über den Autor
Hugo Kubinyi studied chemistry in Vienna, Austria. After his Ph.D. thesis at the Max Planck Institute of Biochemistry in Munich he continued as a PostDoc at the German Cancer Research Centre in Heidelberg. In 1966 he joined Knoll AG, later a subsidiary of BASF AG, and in 1985 he moved to BASF AG. Since 1987, until his retirement in summer 2001, he was responsible for the Molecular Modelling, Protein Crystallography and Drug Design group of BASF, since early 1998 also for Combinatorial Chemistry in the Life Sciences. He is Professor of Pharmaceutical Chemistry at the University of Heidelberg, former Chair of The QSAR and Modelling Society, and IUPAC Fellow. From his scientific work resulted five books on QSAR, 3D QSAR, and Drug Design (the German book Wirkstoffdesign received the 1999 Book Award of the FCI, Association of Chemical Industry) and about 90 publications. He is a member of several Scientific Advisory Boards, coeditor of the Wiley-VCH book series Methods and Principles in Medicinal Chemistry, and member of the Editorial Boards of several scientific journals. Gerhard Müller graduated in Organic Chemistry from the University of Frankfurt/Main (Germany) and received his PhD in 1992 at the Technical University of Munich. After two years in the Medicinal Chemistry department of Glaxo Verona (Italy), he joined the central research facility of the Bayer AG, Leverkusen. From 1998 onwards he was project manager of a target family approach in medicinal chemistry. From 2001 to 2003 he headed the chemistry section of Organon's Lead Discovery Unit in Oss (The Netherlands). Since summer 2003, Gerhard Müller is the chief scientific officer of the Munich-based biotech company Axxima Pharmaceuticals AG.
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