Retrotransposition, Diversity and the Brain
Retroelements are ancient mobile DNA found in most organisms. Long dismissed as useless, selfish or junk DNA, they were thought to be mere intracellular parasites from our distant evolutionary past. Together with their mutant relatives, L1 sequences constitute almost 50% of the mammalian genome. L1s can retrotranspose in a defined window of the neuronal differentiation, changing the genetic information in single neurons in a random fashion, allowing the brain to develop in distinct different ways. Such strategy contributes to expand the number of functionally distinct neurons that could be produced from a given stem cell gene pool. This chara…
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Produktdetails
- ISBN: 978-3-642-09437-8
- EAN: 9783642094378
- Produktnummer: 10559214
- Verlag: Springer Berlin Heidelberg
- Sprache: Englisch
- Erscheinungsjahr: 2010
- Seitenangabe: 136 S.
- Masse: H23.5 cm x B15.5 cm x D0.7 cm 219 g
- Auflage: Softcover reprint of hardcover 1st ed. 2008
- Abbildungen: Paperback
- Gewicht: 219
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