Malaria: Genetic and Evolutionary Aspects

This book is an edited collection of papers by leading experts on the population genetics and evolutionary biology of malaria, a disease which results in three million deaths each year in the world. Malaria Hypothesis refers to the hypothesis, which was proposed by J.B.S. Haldane at the 8th International Congress of Genetics in Stockholm in 1948, that the identical geographic distribution of both falciparum malaria and thalassemia in the mediterranean region suggests that the heterozygous individuals for thalassemia (or microcythemia as it was called then) might have greater resistance to malarial infection. Haldane, later in the same year, expanded his theory to infectious disease in general at another international conference, at Pallanza in Italy. Haldane's hypothesis was subsequently confirmed in the African populations by A.C. Allison and later by others during the last fifty years, although at first for sickle cell anemia and later for thalassemia with varying degrees of success. The malaria hypothesis still remains today a unique example of that kind of balanced polymorphism, not only in genetics but in all of biology. It opened up new insights into our perspective of the genetics and population dynamics of disease prevalence, particularly infectious disease. TOC:Preface.- Introduction. Malaria: Genetic and Evolutionary aspects.- J.B.S. Haldane (1892-1964).- Removal of Early parasite forms from circulation as a mechanism of resistance against malaria in widespread redblood cell mutations.- Clinical, epidemiological and genetic investigations of thalassemia and malaria in Italy.- Resistance to antimalarial drugs: Parasite and Host Genetic factors.- Evolutionary origins of human malaria parasites.- Vector Genetics in Malaria Control.- The rate of mutation of human genes.- Disease and evolution.