Raimund (Reihe Hrsg.) Mannhold
Combinatorial Chemistry
From Theory to Application
Ebook (PDF Format)
This revolutionary method enables organic and medicinal chemists to synthesize thousands or even millions of potentially interesting compounds in a single reaction sequence. Combined with current methods of high throughput analysis, combinatorial methods have almost completely replaced the traditional step-by-step synthesis of potential drugs. Retaining its practice-oriented approach, this new edition has been thoroughly updated to reflect recent developments in parallel synthesis, while a new chapter on screening complements the overview of combinatorial strategy and synthetic methods. The result is a handbook tailored to the needs of the i…
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Beschreibung
This revolutionary method enables organic and medicinal chemists to synthesize thousands or even millions of potentially interesting compounds in a single reaction sequence. Combined with current methods of high throughput analysis, combinatorial methods have almost completely replaced the traditional step-by-step synthesis of potential drugs. Retaining its practice-oriented approach, this new edition has been thoroughly updated to reflect recent developments in parallel synthesis, while a new chapter on screening complements the overview of combinatorial strategy and synthetic methods. The result is a handbook tailored to the needs of the industry, with almost all the authors affiliated with leading pharmaceutical companies. From the contents: Purification Principles in High-Speed Solution Phase Synthesis Linkers for Solid-Phase Organic Synthesis (SPOS) and Combinatorial Approaches on Solid Support Cyclative Cleavage - A Versatile Concept in Solid-Phase Organic Chemistry C-C Bond Forming Reactions Combinatorial Synthesis of Heterocycles Polymer-Supported Reagents: Preparation and Use in Parallel Organic Synthesis Encoding Strategies for Combinatorial Libraries Automation and Devices for Combinatorial Chemistry and Parallel Organic Synthesis Assays for High Throughput Screening in Drug Discovery Computer-Assisted Library Design Appendix: Cheminformatics and Web Resources for Combinatorial Chemistry For organic and medicinal chemists, chemists in industry, and the pharmaceutical industry.
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Produktdetails
Weitere Autoren: Folkers, Gerd (Reihe Hrsg.) / Kubinyi, Hugo (Reihe Hrsg.) / Hinzen, Berthold (Hrsg.) / Bannwarth, Willi (Hrsg.)
- ISBN: 978-3-527-60738-9
- EAN: 9783527607389
- Produktnummer: 13857984
- Verlag: Wiley-Vch
- Sprache: Englisch
- Erscheinungsjahr: 2006
- Seitenangabe: 694 S.
- Plattform: PDF
- Masse: 20'899 KB
- Auflage: 2. Aufl.
Über den Autor
Willi Bannwarth is full Professor for Organic Chemistry at the Albert-Ludwigs University Freiburg (Germany). Having studied Chemistry in Munster and Konstanz, he worked as a postdoctoral fellow with Sir A. Battersby in Cambridge (UK). In 1979, he joined Roche in Basel (Switzerland) where he was head of nucleotide and peptide chemistry and later was named head of combinatorial chemistry, a technique which he had introduced at Roche. In 1996 he moved to Byk Gulden Pharmaceuticals (now Altanapharma) in Konstanz to build a cominatorial chemistry facility there. In 1999 he was appointed professor for Organic chemistry at the University of Freiburg where he focuses on combinatorial and bioorganic chemistry.
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