Insights into Receptor Function and New Drug Development Targets
G-Protein Coupled receptors (GPCRs) and other receptors are significant targets for drug discovery, due to their roles in fundamental physiological processes. Among these roles are: regulation of growth, food intake, reproduction, water balance, sensory perception, blood pressure and heart rate. GPCR-directed drugs account for approximately $40 billion in sales and, of drugs at market, approximately 70% target GPCR function.The availability of combinatorial chemistry coupled with high throughput screening techniques have facilitated discovery of peptidic and non-peptidic ligands of membrane receptors. Mutant receptor models have revealed thei…
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Produktdetails
Weitere Autoren: Kordon, Claude (Hrsg.)
- ISBN: 978-3-642-07080-8
- EAN: 9783642070808
- Produktnummer: 10559749
- Verlag: Springer Berlin Heidelberg
- Sprache: Englisch
- Erscheinungsjahr: 2010
- Seitenangabe: 220 S.
- Masse: H23.5 cm x B15.5 cm x D1.2 cm 341 g
- Auflage: Softcover reprint of hardcover 1st ed. 2006
- Abbildungen: Paperback
- Gewicht: 341
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