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Wei-Chiang (Hrsg.) Shen

Antibody-Drug Conjugates

The 21st Century Magic Bullets for Cancer

Buch

This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently iss… Mehr

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Produktdetails


Weitere Autoren: Wang, Jeffrey (Hrsg.) / Zaro, Jennica L. (Hrsg.)
  • ISBN: 978-3-319-37669-1
  • EAN: 9783319376691
  • Produktnummer: 21255233
  • Verlag: Springer International Publishing
  • Sprache: Englisch
  • Erscheinungsjahr: 2016
  • Seitenangabe: 264 S.
  • Masse: H23.5 cm x B15.5 cm x D1.4 cm 406 g
  • Auflage: Softcover reprint of the original 1st ed. 2015
  • Abbildungen: Paperback
  • Gewicht: 406

Über den Autor


Dr. Jeffrey Wang received his PhD in pharmaceutical sciences from the University of Southern California in Los Angeles.  Dr. Wang's research focuses on the application of principles of pharmacokinetics and drug metabolism in drug discovery and delivery, particularly in anti-cancer drug discovery and peptide and protein drug delivery.  He has published more than 100 peer-reviewed articles, book chapters and meeting abstracts and is the co-inventor of several U.S. and international patents.  Dr. Wang is currently Associate Professor of Pharmaceutical Sciences and Director of Graduate Education at the College of Pharmacy, Western University of Health Sciences, Pomona, California. Dr. Wei-Chiang Shen is John A. Biles Professor in Pharmaceutical Sciences at the University of Southern California's School of Pharmacy in Los Angeles.  Dr. Shen received his PhD in bio-organic chemistry from Boston University, Massachusetts.  He has many years of experience on the conjugation of drug to macromolecules, including poly (amino acids), transferrin and antibodies.  His current focus of research is on recombinant fusion proteins and cell-penetrating peptides.  Dr. Shen has published about 150 papers, mostly in the area of drug delivery.  He is an inventor or co-inventor of 16 issued U.S. patents and a Fellow of the American Association of Pharmaceutical Scientists and the American Association for the Advancement of Science. Dr. Jennica L. Zaro is a Research Assistant Professor at the School of Pharmacy, University of Southern California, Los Angeles.  Her main research projects are focused on targeted delivery of peptide and protein drugs and on recombinant bifunctional fusion proteins as therapeutics.  Dr. Zaro is also the Core Director of the Translational Research Laboratory.  Prior to joining the university, Dr. Zaro received her PhD in pharmaceutical sciences from the University of Southern California, where she focused on the design and characterization of peptide carriers for protein drugs.  In addition, she has held several roles in the pharmaceutical industry, where she developed formulations for aerosol products and designed and validated analytical methods for protein drugs.

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