Pharmacophores and Pharmacophore Searches
In their search for new drugs, medicinal chemists are trying to pinpoint and optimize only the active part of a pharmaceutical substance, without interference from other parts of the molecule. The pharmacophore is a virtual representation of the active part of a drug that enables them to do just that. Once identified, pharmacophores can then be used for the screening of drug libraries and drug targets to find novel active substances that can be developed into drugs. This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field, progressing from general considerations to real lif…
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Produktdetails
Weitere Autoren: Folkers, Gerd (Reihe Hrsg.) / Kubinyi, Hugo (Reihe Hrsg.) / Hoffmann, Rémy D. (Hrsg.) / Langer, Thierry (Hrsg.)
- ISBN: 978-3-527-60872-0
- EAN: 9783527608720
- Produktnummer: 13860696
- Verlag: Wiley-Vch
- Sprache: Englisch
- Erscheinungsjahr: 2006
- Seitenangabe: 395 S.
- Plattform: PDF
- Masse: 20'188 KB
Über den Autor
Thierry Langer (b. 1962) is heading the Computer Aided Molecular Design Group at the University of Innsbruck (Tyrol, Austria). After his pharmacy M.S. degree (1987) he obtained a Ph.D. degree in organic chemistry at the University of Vienna (Austria) in 1991. He then spent one year as a post-doc fellow at the Universiteacute; Louis Pasteur (Strasbourg, France) with C. G. Wermuth. In 1992 he moved to the University of Innsbruck, where he established the molecular modeling group. Since 1997 he is associate professor for pharmaceutical chemistry. In addition to his academic appointments, he is also the founder and CEO of the Inteligand, a company specialized in providing computational services for the pharmaceutical industry. Professor Langer's main research interests are focused on theoretical pharmaceutical chemistry, drug design, and pharmacophore modeling using molecular modeling techniques as well as QSAR and 3D-QSAR.
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