Antitargets
Prediction and Prevention of Drug Side Effects
Addressing a common challenge that is faced by every drug developer, this practice-oriented handbook surveys current knowledge on the occurrence and prevention of adverse drug reactions related to off-target activity of small molecule drugs. It is unique in collating the current approaches into a single source, and includes several highly instructive case studies that may be used as guidelines on how to improve drug development projects. Clearly divided into four parts, the first covers general considerations of studying and predicting side effects in drug molecules, while the second part looks at well-known anti-targets that mediate severe s…
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Produktdetails
Weitere Autoren: Folkers, Gerd (Reihe Hrsg.) / Kubinyi, Hugo (Reihe Hrsg.) / Klabunde, Thomas (Hrsg.) / Vaz, Roy J. (Hrsg.)
- ISBN: 978-3-527-62147-7
- EAN: 9783527621477
- Produktnummer: 13901800
- Verlag: Wiley-Vch
- Sprache: Englisch
- Erscheinungsjahr: 2008
- Seitenangabe: 504 S.
- Plattform: PDF
- Masse: 17'426 KB
Über den Autor
Roy Vaz is the head of investigative pharmacokinetics at the Bridgewater, NJ (USA) location of Sanofi-Aventis Pharmaceuticals. He received his Ph.D. in Organic Chemistry from the University of Florida, Gainesville (USA), after graduating from the Indian Institute of Technology in Mumbai (India). Prior to his present appointment, he has worked with Bristol-Myers-Squibb and Tripos. He is a specialist on the prediction and modeling of cytochrome-mediated drug metabolism. Thomas Klabunde obtained his PhD in chemistry from the University of Munster (Germany). After a postdoctoral fellowship at the Texas A&M University, he was appointed Assistant Professor at the Institute for Bioscience and Technology in Houston (USA). Later on, he joined the pharmaceutical research of Sanofi-Aventis in Frankfurt (Germany), where he is currently a group leader. His main interest lies with drug design approaches for G protein-coupled receptors, notably in the areas of lead finding and chemogenomics.
100 weitere Werke von Raimund (Reihe Hrsg.) Mannhold:
Chemoinformatics in Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 242.00
Protein Crystallography in Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 170.00
Aspartic Acid Proteases as Therapeutic Targets
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 186.00
Protein Kinases as Drug Targets
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 156.00
G Protein-Coupled Receptors as Drug Targets
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 215.00
Proteomics in Drug Research
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 209.00
Molecular Descriptors for Chemoinformatics
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 425.00
Advanced Computer-Assisted Techniques in Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 151.00
Transporters as Drug Carriers
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 193.00
Chemogenomics in Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 220.00
Evolutionary Algorithms in Molecular Design
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 164.00
Data Mining in Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 153.00
Scaffold Hopping in Medicinal Chemistry
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 153.00
Phosphodiesterases and Their Inhibitors
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 131.00
Ligand Design for G Protein-coupled Receptors
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 200.00
Protein-Ligand Interactions
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 156.00
Microwaves in Organic and Medicinal Chemistry
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 198.00
Combinatorial Chemistry
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 182.00
Chemokine Receptors as Drug Targets
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 159.00
Protein-Ligand Interactions
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 156.00
Protein-Protein Interactions in Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 156.00
Drug Metabolism Prediction
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 164.00
Epigenetic Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 175.00
Epigenetic Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 195.00
Innovative Dosage Forms
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 195.00
Neglected Tropical Diseases
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 195.00
Target Discovery and Validation
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 175.00
Innovative Dosage Forms
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 195.00
Drug Metabolism Prediction
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 164.00
Solid State Development and Processing of Pharmaceutical Molecules
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 207.70
New Drug Development for Known and Emerging Viruses
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 429.00
Microwaves in Organic and Medicinal Chemistry
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 198.00
Pharmacophores and Pharmacophore Searches
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 193.00
Protein-Ligand Interactions
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 153.00
Fragment-based Approaches in Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 220.00
Pharmacokinetics and Metabolism in Drug Design
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 122.00
Bioisosteres in Medicinal Chemistry
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 137.00
Natural Products in Medicinal Chemistry
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 175.00
Medicinal Chemistry Approaches to Personalized Medicine
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 153.00
Bioisosteres in Medicinal Chemistry
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 137.00
Protein-Protein Interactions in Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 156.00
Phosphodiesterases and Their Inhibitors
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 131.00
In vivo Models for Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 164.00
Protein Therapeutics, 2 Volume Set
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 175.00
Protein Therapeutics, 2 Volume Set
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 175.00
Transporters as Drug Targets
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 164.00
Transporters as Drug Targets
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 164.00
Early Drug Development
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 308.00
Neglected Tropical Diseases
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 195.00
Fragment-based Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 164.00
Reactive Drug Metabolites
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 156.00
Quantum Medicinal Chemistry
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 170.00
Molecular Biology in Medicinal Chemistry
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 198.00
Antiviral Drug Strategies
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 159.00
Mass Spectrometry in Medicinal Chemistry
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 215.00
Molecular Interaction Fields
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 198.00
Prodrugs and Targeted Delivery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 164.00
Virtual Screening for Bioactive Molecules
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 164.00
Structure-based Ligand Design
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 153.00
Lipophilicity in Drug Action and Toxicology
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 127.00
Aspartic Acid Proteases as Therapeutic Targets
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 186.00
Solid State Development and Processing of Pharmaceutical Molecules
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 207.70
New Drug Development for Known and Emerging Viruses
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 386.00
Prodrugs and Targeted Delivery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 164.00
Nuclear Receptors as Drug Targets
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 215.00
Pharmacokinetics and Metabolism in Drug Design
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 137.00
Reactive Drug Metabolites
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 156.00
Data Mining in Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 153.00
Natural Products in Medicinal Chemistry
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 175.00
Scaffold Hopping in Medicinal Chemistry
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 153.00
Medicinal Chemistry Approaches to Personalized Medicine
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 153.00
Voltage-Gated Ion Channels as Drug Targets
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 215.00
Chemokine Receptors as Drug Targets
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 159.00
Combinatorial Chemistry
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 253.00
Chemometric Methods in Molecular Design
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 153.00
High-Throughput Screening in Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 198.00
Handbook of Molecular Descriptors
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 314.00
Drug-Membrane Interactions
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 142.00
In vivo Models for Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 164.00
Target Discovery and Validation
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 175.00
Thermodynamics and Kinetics of Drug Binding
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 164.00
BioNMR in Drug Research
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 198.00
Chirality in Drug Research
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 204.00
Antiviral Drug Strategies
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (EPUB Format)
CHF 159.00
Thermodynamics and Kinetics of Drug Binding
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 164.00
Protein Kinases as Drug Targets
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 156.00
Fragment-based Drug Discovery
Prediction and Prevention of Drug Side Effects
Prediction and Prevention of Drug Side Effects
Ebook (PDF Format)
CHF 164.00
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