Shh and Gli Signalling and Development

This book reviews what is known about the Sonic Hedgehog pathway and the downstream Gli transcription factors during development. An introductory chapter reviews the pathway both in invertebrates and vertebrates. Subsequent chapters deal with the role of Shh during the development of specific organs and body systems in a variety of organisms including zebrafish, mouse and man. The book can be read in its entirety to provide readers with a comprehensive review of the importance of this signalling pathway for normal development and insights into on-going research in this field. Such an approach may be useful for under graduates or post-graduate students with an interest in development, cell signalling cascades or those specifically researching some aspect of Shh. TOC:Introduction.- Sonic Hedgehog Signalling in Dorsal Midline and Neural Development.- Role of Hedgehog and Gli Signalling in Telencephalic Development.- Role of Shh and Gli Signalling in Oligodendroglial Development.- The Role of Sonic Hedgehog Signalling in Craniofacial Development.- Multiple Roles for Hedgehog Signalling in Zebrafish.- Sonic Hedgehog Signalling during Tooth Morphogenesis.- Limb Pattern Formation: Upstream and Downstream of Shh Signalling.- Sonic Hedgehog Signalling in the Developing and Regenerating Fins of Zebrafish.- Hedgehog Signalling in T Lymphocyte Development.- Hedgehog Signalling in Prostate Morphogenesis.- Sonic Hedgehog Signalling in Visceral Organ Development.- Shh/Gli Signalling during Murine Lung Development.- New Perspectives in Shh Signalling?