Protein Homology Detection Through Alignment of Markov Random Fields
Using MRFalign
This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result…
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Produktdetails
Weitere Autoren: Ma, Jianzhu / Wang, Sheng
- ISBN: 978-3-319-14914-1
- EAN: 9783319149141
- Produktnummer: 18253458
- Verlag: Springer
- Sprache: Englisch
- Erscheinungsjahr: 2015
- Plattform: PDF
- Masse: 2'709 KB
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