Metabolism, Pharmacokinetics and Toxicity of Functional Groups: Impact of the Building Blocks of Medicinal Chemistry on ADMET
This outstanding book provides insight into the metabolism, pharmacokinetics and toxicity (ADMET) of chemicals by dividing the subject into functional groups. Following a description of chemical space and general ADMET in a unique way, by referring to actual chemical structures (functional groups) which even influence the molecules, they are incorporated into, in a specific manner. Many of the groupings are characterise the pharmacology of the drugs and are essential for particular activity; they are also a major influence in changing ADMET characteristics. These changes follow a pattern, thus allowing medicinal chemists to understand likely…
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Produktdetails
Weitere Autoren: Fox, David (Hrsg.)
- ISBN: 978-1-84973-016-7
- EAN: 9781849730167
- Produktnummer: 6358275
- Verlag: Royal Society Of Chemistry
- Sprache: Englisch
- Erscheinungsjahr: 2010
- Seitenangabe: 530 S.
- Masse: H24.3 cm x B16.4 cm x D3.5 cm 937 g
- Reihenbandnummer: 01
- Gewicht: 937
Über den Autor
Professor Dennis Smith has worked in the pharmaceutical industry for 32 years after gaining his Ph.D from the University of Manchester. For 20 years he was at Pfizer Global Research and Development, Sandwich where he was Vice President-Pharmacokinetics, Dynamics and Metabolism. For the past 2 years he has been a Pfizer Academic Research Fellow working on a part-time basis. His research interests and publications span all aspects of Drug Discovery and Development particularly where drug metabolism knowledge can impact on the design of more efficacious and safer drugs. During this 30-year span he has helped in the Discovery and Development of eight marketed NCEs. He has authored over 100 publications including two books.
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