Defining Optimal Immunotherapies for Type 1 Diabetes
Type 1 diabetes (T1D) can be managed by administration of insulin, but the search continues for a more permanent cure. Hopes were high in the early 1990s, when the similarity between mouse and human MHC class II diabetes susceptibility genes had been discovered, and a cure seemed at hand via modulating interactions between CD4+ T cells and such MHC molecules. Unfortunately pathogenesis of T1D is much more complex, polygenic, dependent on disease penetrance on multiple environmental factors, and likely to involve the participation of CD4+, CD8+ and B lymphocytes. Additionally, islet ?-cell destruction might involve mechanisms that differ amon…
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Produktdetails
Weitere Autoren: Goode, Jamie A. (Hrsg.)
- ISBN: 978-0-470-69741-2
- EAN: 9780470697412
- Produktnummer: 13907672
- Verlag: Wiley
- Sprache: Englisch
- Erscheinungsjahr: 2008
- Seitenangabe: 222 S.
- Plattform: PDF
- Masse: 2'037 KB
Über den Autor
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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