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Dennis A. (Hrsg.) Smith

Metabolite Safety in Drug Development

Ebook (EPUB Format)

Metabolism is the primary method to clear a drug from the body, but the normal process can generate metabolites that have intrinsic chemical reactivity towards cellular molecules-and these metabolites remain free to circulate and exert both pharmacological and toxicological effects. Therefore, the study of drug metabolism occurs at all stages in the drug discovery and drug development process. Targeting practitioners in all areas of nonclinical toxicology and clinical development, Metabolite Safety in Drug Development focuses on the characterization of metabolites once a drug candidate is selected, featuring case studies to illustrate lessons… Mehr

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Produktdetails


Weitere Autoren: Iverson, Suzanne L. (Hrsg.)
  • ISBN: 978-1-118-94967-2
  • EAN: 9781118949672
  • Produktnummer: 20245837
  • Verlag: Wiley
  • Sprache: Englisch
  • Erscheinungsjahr: 2016
  • Seitenangabe: 352 S.
  • Plattform: EPUB
  • Masse: 14'424 KB

Über den Autor


Suzanne L. Iverson, PhD, ERT, earned her PhD studying reactive drug metabolites and idiosyncratic drug reactions (University of Toronto, Dr. Jack Uetrecht supervisor) and has worked in the pharmaceutical industry for over 14 years as principal scientist and manager of development in vitro/in vivo metabolism and distribution imaging as well as functional project leader for both DMPK and safety assessment functions. Since 2011, she has served on the management committee of the Drug Metabolism Discussion Group, UK, and the Board of the PK-Metabolism subcommittee of the Swedish Pharmaceutical Society. Dennis A. Smith, PhD, currently holds part-time advisory and academic positions and, previously, worked in the pharmaceutical industry for 32 years. He has coauthored over 150 publications, including Attrition in the Pharmaceutical Industry (Wiley, 2016), Reactive Drug Metabolites (Wiley, 2012), and three editions of the book Pharmacokinetics and Metabolism in Drug Design (Wiley, 2012).

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