Oligonucleotides as Therapeutic Agents
The use of oligonucleotides as therapeutic agents rests upon their ability to interfere, in a sequence-specific manner, with the fundamental machinery of protein synthesis either by binding to the mRNAs transcribed from a gene or by binding directly to a target gene. This approach can be used not only for inhibition of the synthesis of host proteins but also of those required by invading pathogens. Potential therapeutic applications are enormous, ranging over hypertension, cardiovascular disease, autoimmune disease, vital and other parasitic infections (especially HIV), and cancer. This book discusses the chemistry and pharmacokinetics of oli…
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Produktdetails
Weitere Autoren: Cardew, Gail (Hrsg.)
- ISBN: 978-0-470-51540-2
- EAN: 9780470515402
- Produktnummer: 13955476
- Verlag: Wiley
- Sprache: Englisch
- Erscheinungsjahr: 2008
- Seitenangabe: 260 S.
- Plattform: PDF
- Masse: 13'862 KB
Über den Autor
Derek J. Chadwick and Gail Cardew are editors for Oligonucleotides as Therapeutic Agents and other scientific titles.
69 weitere Werke von Derek J. (Hrsg.) Chadwick:
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