Randomization in Clinical Trials

Praise for the First Edition: All medical statisticians involved in clinical trials should read this book?-Controlled Clinical Trials   Featuring a unique combination ofthe applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go-to guide for biostatisticians and pharmaceutical industry statisticians. A consolidated review of the field, the Second Edition focuses on computation of randomized tests rather than the asymptotic theory of randomized tests.  Randomization in Clinical Trials: Theory and Practice, Second Edition features: A discussion on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials A new chapter on covariate-adjusted response-adaptive randomization, including minimization techniques and inference for covariate-adaptive randomization New developments in restricted randomization and an increased focus on computation of randomization tests as opposed to the asymptotic theory of randomization tests Many problem sets, theoretical exercises, and short computer simulations using SAS® to facilitate classroom teaching, to simplify the mathematics, and to ease understanding Randomization in Clinical Trials: Theory and Practice, Second Edition is an excellent reference for researchers as well as applied statisticians and biostatisticians. The Second Edition is also an ideal textbook for upper-undergraduate and graduate-level courses in biostatistics and applied statistics.