The Tumor Microenvironment
The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- e…
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Produktdetails
- ISBN: 978-1-4419-6614-8
- EAN: 9781441966148
- Produktnummer: 6880729
- Verlag: Springer Nature
- Sprache: Englisch
- Erscheinungsjahr: 2010
- Seitenangabe: 767 S.
- Masse: H24.2 cm x B16.7 cm x D3.8 cm 1'428 g
- Auflage: Edition
- Gewicht: 1428
Über den Autor
Rebecca Bagley is a senior scientist at Genzyme Corporation and has worked in the biotechnology industry for 20 years with degrees in biology from Wellesley College and Harvard University. Her expertise in drug development spans a wide range of approaches including immunotherapies, gene and protein therapies, and small molecule delivery with publications in journals such as Molecular Cancer Therapeutics, Cancer Research, and Microvascular Research . Her current research focuses on stem cells, tumor vasculature, and target validation.
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