Sajal (Hrsg.) Chakraborti
Regulation of Membrane Na+-K+ ATPase
Ebook (PDF Format)
Na+-K+ ATPase or Na-pump ATPase, a member of P-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it's ?- and ?- subunits. At present four different ?- (?-1,?-2,?-3 and ?-4) and three ?- (?-1, ?-2, and ?-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dep…
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Beschreibung
Na+-K+ ATPase or Na-pump ATPase, a member of P-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it's ?- and ?- subunits. At present four different ?- (?-1,?-2,?-3 and ?-4) and three ?- (?-1, ?-2, and ?-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of ?- and ?- subunits leading to an increased expression in the level of Na+-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembrane domain adjacent to the isoform(s) of ?-? subunits of Na+-K+ ATPase. Considering the extraordinary importance of Na+-K+ ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled Regulation of Membrane Na+-K+ ATPase for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ ATPase regulation in health and disease.
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Produktdetails
Weitere Autoren: Dhalla, Naranjan S (Hrsg.)
- ISBN: 978-3-319-24750-2
- EAN: 9783319247502
- Produktnummer: 19290032
- Verlag: Springer-Verlag GmbH
- Sprache: Englisch
- Erscheinungsjahr: 2015
- Seitenangabe: 436 S.
- Plattform: PDF
- Masse: 15'511 KB
- Auflage: 1st ed. 2016
- Abbildungen: 56 schwarz-weiße und 44 farbige Abbildungen, 16 schwarz-weiße Tabellen, Bibliographie
- Reihenbandnummer: 15
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