Protein-Ligand Interactions
From Molecular Recognition to Drug Design
Das von Emil Fischer bereits Ende des 19. Jahrhunderts formulierte Schlüssel-Schloss Prinzip hat auch im 21. Jahrhundert nichts von seiner grundlegenden Bedeutung für die Biowissenschaften verloren. Heute werden die Grundlagen der Ligand-Protein-Wechselwirkung unter dem Begriff 'Molekulare Erkennung' zusammengefasst und betreffen Aspekte sowohl der Stabilität wie der Spezifität der Ligandenbindung. Die Molekulare Erkennung ist damit eine Kernfrage in der Wirkstoffentwicklung , denn Stabilität und Spezifität bestimmen maßgeblich darüber, ob ein Stoff als Medikament eingesetzt werden kann. Bei der Suche nach immer besseren Liganden leisten inzw…
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Produktdetails
Weitere Autoren: Folkers, Gerd (Reihe Hrsg.) / Kubinyi, Hugo (Reihe Hrsg.) / Schneider, Gisbert (Hrsg.) / Böhm, Hans-Joachim (Hrsg.)
- ISBN: 978-3-527-60551-4
- EAN: 9783527605514
- Produktnummer: 13872712
- Verlag: Wiley-Vch
- Sprache: Englisch
- Erscheinungsjahr: 2006
- Seitenangabe: 262 S.
- Plattform: PDF
- Masse: 4'085 KB
Über den Autor
Hans-Joachim Bohm is the editor of Protein-Ligand Interactions: From Molecular Recognition to Drug Design, published by Wiley. Gisbert Schneider is full professor of computer-assisted drug design at ETH Zurich, Switzerland. He studied biochemistry and computer science at the Free University of Berlin, Germany.
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