Ligand Design for G Protein-coupled Receptors
G protein-coupled receptors (GPCRs) are important switches in biological signal transduction and constitute the most numerous protein class in higher organisms, reflecting their involvement in the hormonal regulation of virtually all body processes. This regulatory function makes them prime drug targets, and many blockbuster drugs act either directly or indirectly on GPCRs. Yet it is only with the recent elucidation of the rhodopsin structure that these receptors have become amenable to a rational drug design. This is the first work to describe in detail the structure-based rational approach to GPCR drug design. Based on recent examples from…
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Produktdetails
Weitere Autoren: Folkers, Gerd (Reihe Hrsg.) / Kubinyi, Hugo (Reihe Hrsg.) / Rognan, Didier (Hrsg.)
- ISBN: 978-3-527-60826-3
- EAN: 9783527608263
- Produktnummer: 13877809
- Verlag: Wiley-Vch
- Sprache: Englisch
- Erscheinungsjahr: 2006
- Seitenangabe: 284 S.
- Plattform: PDF
- Masse: 11'172 KB
Über den Autor
Didier Rognan leads the Drug Bioinformatics Group at the Laboratory for Molecular Pharmacochemistry in Illkirch (France). He obtained a graduate degree in Pharmacy from the University of Rennes and completed his PhD in Medicinal Chemistry at the University of Strasbourg under the supervision of Camille G. Wermuth in 1989. Moving to the Swiss Federal Institute of Technology in Zürich he became Assistant Professor at the ETH before being named a research director at the CRNS in Illkirch near Strasbourg in 2000. Professor Rognan is mainly interested in all aspects (method development, applications) of protein-based drug design and virtual screening.
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