P2 Purinoceptors
Localization, Function and Transduction Mechanisms
The potent biological actions of the purine nucleotides and nucleosides, adenosine and ATP, have been recognized since 1929, and the clinical effects in humans of administration of ATP have been explored since the 1950s. However, it was not until 1972 that purinergic neurotransmission was proposed, and later, in 1978, the existence of specific receptors for extracellular ATP that recognize the triphosphate nucleotide, but not adenosine, was established. These receptors have been referred to as P2 purinoceptors whereas those responding to adenosine have been termed P1 purinoceptors. Pharmacological evidence has led to further subclassification…
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Produktdetails
Weitere Autoren: Chadwick, Derek J. (Hrsg.)
- ISBN: 978-0-470-51491-7
- EAN: 9780470514917
- Produktnummer: 13965170
- Verlag: Wiley
- Sprache: Englisch
- Erscheinungsjahr: 2008
- Seitenangabe: 346 S.
- Plattform: PDF
- Masse: 18'631 KB
Über den Autor
Derek J. Chadwick and Jamie A. Goode are editors for P2 Purinoceptors: Localization, Function and Transduction Mechanisms and other scientific titles.
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