Defining Optimal Immunotherapies for Type 1 Diabetes
Type 1 diabetes (T1D) can be managed by administration of insulin, but the search continues for a more permanent cure. Hopes were high in the early 1990s, when the similarity between mouse and human MHC class II diabetes susceptibility genes had been discovered, and a cure seemed at hand via modulating interactions between CD4+ T cells and such MHC molecules. Unfortunately pathogenesis of T1D is much more complex, polygenic, dependent on disease penetrance on multiple environmental factors, and likely to involve the participation of CD4+, CD8+ and B lymphocytes. Additionally, islet ²-cell destruction might involve mechanisms that differ among…
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Produktdetails
Weitere Autoren: Goode, Jamie A. (Hrsg.)
- ISBN: 978-0-470-72325-8
- EAN: 9780470723258
- Produktnummer: 4729761
- Verlag: John Wiley & Sons Inc
- Sprache: Englisch
- Erscheinungsjahr: 2008
- Seitenangabe: 222 S.
- Masse: H23.6 cm x B16.3 cm x D1.6 cm 486 g
- Gewicht: 486
- Sonstiges: Professional & Vocational
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