Molecular and Biochemical Toxicology

An essential resource for students, academic, and industrial toxicologists and environmental health scientists Throughout its past editions, this text has been an important source for defining the biochemical, cellular, and molecular events that toxicants induce at the cellular and organismic levels and linking molecular and cellular biology as well as genomic sciences to mechanistic toxicology. Molecular and Biochemical Toxicology provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. Toxicological mechanisms are discussed and described in detail from the biomolecule, pathway, cell, tissue, organ, model organism, human to the individual human population. As the field of toxicology has evolved and advanced so has Molecular and Biochemical Toxicology. Changes in this new edition stress advances in our understanding in how toxicants produce their adverse outcomes as well as the use of cutting-edge technology/methodology in contemporary toxicology. The organization of the 5th edition is divided into sections which include: Techniques in Biochemical and Molecular Toxicology, Mechanisms in Molecular and Biochemical Toxicology, Molecular and Biochemical Aspects of Organ Toxicology; as well as a new section on Emerging Areas in Molecular and Biochemical Toxicology. The fifth edition has been substantially updated and includes 12 new chapters, like those on: nuclear receptors, nanotoxicology, computational and molecular approaches to risk assessment, developmental origins of health and disease, exposome, and basic concepts of molecular epidemiological research methods. Chapters on Omics technologies provide an understanding of these technologies/approaches and how they can be used to understand the complex mechanisms of toxicity. Whether used in the classroom or in industry, research, or academia; Molecular and Biochemical Toxicology remains essential for anyone interested in understanding the molecular mechanisms through which toxicant produce adverse effects.