Drug Transporters

This book offers a comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body. Since publication of the first edition, there have been significant advances in the field: new transporters have been identified, new regulatory pathways have been discovered, and sophisticated techniques for validating transport processes have been developed. These have led to a better understanding of the physiological roles and clinical implications of these transporters. Retaining the same basic format as its predecessor, the second edition of Drug Transporters: Molecular Characterization and Role in Drug Disposition provides an overview of drug transporters and presents the principles of drug transport and associated techniques. Several new chapters are added and others are thoroughly updated or expanded. This new edition overviews drug transporters; including their function, regulation, and role in drug disposition and interactions, as well as experimental approaches for studying drug transport. As a result, this new edition reflects where the field is today and also gives a perspective on the directions for the foreseeable future. ? Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing drug transporters ? Includes new chapters on multidrug and toxin extrusion proteins, placental transport, and in silico approaches in drug discovery ? Has a new chapter covering regulatory guidance for the evaluation of drug transport in drug development with global criteria used for drug transporters in clinical trials ? Provides material ranging from fundamental mechanisms to clinical outcomes, making the book useful for novice and the expert reader