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Mingshe (Hrsg.) Zhu

Drug Metabolism in Drug Design and Development

Basic Concepts and Practice

Ebook (PDF Format)

The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specif… Mehr

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Produktdetails


Weitere Autoren: Zhang, Donglu (Hrsg.) / Humphreys, William G. (Hrsg.)
  • ISBN: 978-0-470-19168-2
  • EAN: 9780470191682
  • Produktnummer: 13894074
  • Verlag: Wiley
  • Sprache: Englisch
  • Erscheinungsjahr: 2007
  • Seitenangabe: 448 S.
  • Plattform: PDF
  • Masse: 5'891 KB

Über den Autor


Donglu Zhang, PhD, is a senior scientist in the Biotransformation Depart-ment at Bristol-Myers Squibb. His research interests include metabolite characterization, drug metabolism enzymology, LC/MS methodologies, and microbial biotransformation. MINGSHE ZHU, PhD, is a drug metabolism scientist with more than ten years of experience in drug discovery and development. His research interests include metabolic activation, LC/MS technology, and regulatory drug metabolism. W. Griffith Humphreys, PhD, is the Director of the Biotransformation Department at Bristol-Myers Squibb. His research interests include optimizationof ADME properties, metabolic activation, and new methodologies for metabolite characterization.

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