Protein Homology Detection Through Alignment of Markov Random Fields
Using MRFalign
This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result…
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Produktdetails
Weitere Autoren: Wang, Sheng / Ma, Jianzhu
- ISBN: 978-3-319-14913-4
- EAN: 9783319149134
- Produktnummer: 17488678
- Verlag: Springer-Verlag GmbH
- Sprache: Englisch
- Erscheinungsjahr: 2015
- Seitenangabe: 51 S.
- Masse: H23.5 cm x B15.5 cm x D0.3 cm 108 g
- Abbildungen: Book; 12 schwarz-weiße und 1 farbige Abbildungen, 17 schwarz-weiße Tabellen, Bibliographie
- Gewicht: 108
1 weiteres Werk von Jinbo Xu:
Protein Homology Detection Through Alignment of Markov Random Fields
Using MRFalign
Using MRFalign
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