Biomarkers in Cancer Screening and Early Detection

Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and clinical use. The primary purpose of this book is to summarize and present best practices in this field to date, and offer actionable information - and hopefully also inspiration - to move discovery and clinical application forward. This latest volume of the Translational Oncology series, Biomarkers in Cancer Screening and Early Detection is organized into three sections: Section I lays the foundation for biomarker discovery, development and validation. Section II presents organ-specific topics relevant to the clinical needs in early detection, the natural history of the disease and associated evidence in support of biomarker research, an overview of the current state-of-the art in biomarker research, current progress toward bringing these biomarkers into clinical use and the future of biomarker-based screening and early detection for the respective organ type. Finally, Section III offers chapters that address the current screening strategies for selected organ types, discuss deficiencies with the present practice and identify clinical needs that may benefit from biomarker-based approaches. This latest volume of the Translational Oncology series, Biomarkers in Cancer Screening and Early Detection: Provides immediately actionable information - and hopefully also inspiration - to move discovery and clinical application forward Considers the cutting edge bench to bedside and back breakthroughs which have transformed the diagnosis, prognosis and treatment of cancer Discusses screening guidelines, research strategies, and issues surrounding cancer overdiagnosis Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers The development of cancer is preceded by numerous mutations and changes which transform normal cells into benign tumors, and progressively into malignant and metastatic forms. This enormous complexity makes cancer detection, diagnosis, and treatment challenging and therefore the ability to identify tumors that are destined to progress at an early stage will allow effective treatment interventions and reduce deaths. This new book comprehensively summarises the current state of play and is an ideal resource for clinical and research oncologists interested in the progress of screening and detection of cancer.