Peptide Chemistry and Drug Design

Discover, develop, produce, and deliver peptide drugs As key players in a number of physiological processes in the human body, peptides have strong benefits and potential as therapeutic agents. While their use as drug candidates has ebbed and flowed in past decades, they are now seen as an excellent way to conduct discovery efforts to learn about the details of protein-ligand interactions and modified peptides may prove to be extremely effective as drugs. This book details many of the problems and successes of peptides as potential drugs, providing a valuable reference and resource for anyone interested in this area of drug discovery. Featuring an assembly of leading international researchers in peptide science, the book overviews separation methods and techniques for analysis in peptide chemistry, as well as the discovery of peptide receptors and inhibitors relevant to drug design. Chapters also detail the synthetic production of peptides, modifications and drug delivery challenges, and results from clinical trials. Collecting otherwise-scattered information from large fields of published literature, this book: ? Identifies promising new areas in peptide drug discovery ? Includes chapters on discovery from natural sources, metabolic modification, and drug delivery ? Overviews bond formation, synthesis, and purification methods ? Serves as both a professional reference and a text or resource for graduate-level students