Video Bioinformatics

Theadvances of live cell video imaging and high-throughput technologies forfunctional and chemical genomics provide unprecedented opportunities tounderstand how biological processes work in subcellular and multicellularsystems. The interdisciplinary research field of Video Bioinformatics isdefined by Bir Bhanu as the automated processing, analysis, understanding, datamining, visualization, query-based retrieval/storage of biologicalspatiotemporal events/data and knowledge extracted from dynamic images andmicroscopic videos. Video bioinformatics attempts to provide a deeperunderstanding of continuous and dynamic life processes.Genomesequences alone lack spatial and temporal information, and video imaging ofspecific molecules and their spatiotemporal interactions, using a range ofimaging methods, are essential to understand how genomes create cells, howcells constitute organisms, and how errant cells cause disease. The book examinesinterdisciplinary research issues and challenges with examples that deal withorganismal dynamics, intercellular and tissue dynamics, intracellular dynamics,protein movement, cell signaling and software and databases for videobioinformatics. Topics and Features·       Covers a set ofbiological problems, their significance, live-imaging experiments, theory and computationalmethods, quantifiable experimental results and discussion of results.·       Provides automatedmethods for analyzing mild traumatic brain injury over time, identifying injurydynamics after neonatal hypoxia-ischemia and visualizing cortical tissuechanges during seizure activity as examples of organismal dynamics·       Describes techniques forquantifying the dynamics of human embryonic stem cells with examples of celldetection/segmentation, spreading and other dynamic behaviors which areimportant for characterizing stem cell health·       Examines and quantifiesdynamic processes in plant and fungal systems such as cell trafficking, growthof pollen tubes in model systems such as Neurospora Crassa and Arabidopsis·       Discusses the dynamicsof intracellular molecules for DNA repair and the regulation of cofilin transportusing video analysis·       Discusses software,system and database aspects of video bioinformatics by providing examples of 5Dcell tracking by FARSIGHT open source toolkit, a survey on available databasesand software, biological processes for non-verbal communications andidentification and retrieval of moth imagesThisunique text will be of great interest to researchers and graduate students ofElectrical Engineering, Computer Science, Bioengineering, Cell Biology,Toxicology, Genetics, Genomics, Bioinformatics, Computer Vision and PatternRecognition, Medical Image Analysis, and Cell Molecular and DevelopmentalBiology. The large number of example applications will also appeal toapplication scientists and engineers.Dr. Bir Bhanu isDistinguished Professor of Electrical & Computer Engineering, Interim Chairof the Department of Bioengineering, Cooperative Professor of Computer Science& Engineering, and Mechanical Engineeringand the Director of the Center for Research in Intelligent Systems, at theUniversity of California, Riverside,California, USA.Dr.Prue Talbot is Professor of Cell Biology & Neuroscience and Director of theStem Cell Center and Core at the University ofCalifornia Riverside, California, USA.