Vaccine Delivery Strategies

Written by leading experts in the field, this book examines the current state of research of all the most important and modern vaccine delivery systems available to date. The immunological principles upon which these systems are based, their potential applications and current clinical status are detailed. Topics covered include: bacterial polysaccharide conjugate vaccines, virosomes and liposomes, bacterial ghosts, attenuated Salmonella and Shigella vaccines, vaccines against tumors, edible vaccines and much more. TOC:Bacterial Polysaccharide Conjugate Vaccines * Novel Adjuvants *Transcutaneous Immunization * Virosomes and Liposomes in Vaccinology *Enhancing DNA Vaccine Efficacy by Stress Protein-Facilitated AntigenExpression * CpG Motifs in Vaccination * Bacterial Ghosts as Carrierand Targeting Systems for Antigen Delivery * Attenuated Salmonella andShigella Live Vectors * Use of the a-Hemolysin Secretion System (TypeI) of Escherichia coli in Vaccine Development * Use of Type IIISecretion Systems to Induce MHC Class I-Restricted Immune Responses *Live Mycobacterial Vaccine Candidates * Delivery of Protein Antigensand DNA Vaccines by Listeria monocytogenes * Transfer of EukaryoticExpression Plasmids to Mammalian Host Cells by Gram-negative Bacteria* Recombinant Intra-cellular Bacteria as Carriers for Tumor Antigens *Dendritic Cell-Based Vaccination against Tumors and InfectiousDiseases * Edible Vaccines