Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals
This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1…
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Produktdetails
- ISBN: 978-981-1681-65-3
- EAN: 9789811681653
- Produktnummer: 38245651
- Verlag: Springer Nature Singapore
- Sprache: Englisch
- Erscheinungsjahr: 2022
- Seitenangabe: 172 S.
- Masse: H24.1 cm x B16.0 cm x D1.5 cm 430 g
- Auflage: 1st ed. 2022
- Abbildungen: HC runder Rücken kaschiert
- Gewicht: 430
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