Toll-like Receptors in Health and Disease
The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2,…
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Produktdetails
- ISBN: 978-3-031-06511-8
- EAN: 9783031065118
- Produktnummer: 39088240
- Verlag: Springer International Publishing
- Sprache: Englisch
- Erscheinungsjahr: 2022
- Seitenangabe: 324 S.
- Masse: H24.1 cm x B16.0 cm x D2.2 cm 711 g
- Auflage: 1st ed. 2022
- Abbildungen: HC runder Rücken kaschiert
- Reihenbandnummer: 276
- Gewicht: 711
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