Hao Yang

Thioorganic-Boronic Acid Desulfitative Coupling

A Desulfitative Strategy to Synthesize Peptidyl Ketone in High Enantiopurity and Application to Total Synthesis of Natural Products

Buch

A background of desulfitative cross coupling of thioorganic compounds and boronic acids is well introduced in chapter 1. Desulfitative cross coupling reactions are successfully applied to synthesize organo nitrile, alkyne, heterocycle, amidine. As an efficient and very mild reaction, desulfitative cross coupling is the best way to prepare high enantiopurity alpha-amino ketone and peptidyl ketone. The major part of this book describes how to develop the chemistry of palladium catalyzed N-protected peptidyl thiol ester and boronic acid cross coupling to generate peptidyl ketone with high yield and enantiopurity. Moreover, this methodology has b… Mehr

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Produktdetails

ISBN: 978-3-8383-1551-5
EAN: 9783838315515
Produktnummer: 37395223
Verlag: LAP Lambert Academic Publishing
Sprache: Englisch
Erscheinungsjahr: 2009
Seitenangabe: 192 S.
Masse: H22.0 cm x B15.0 cm x D1.2 cm 304 g
Abbildungen: Paperback
Gewicht: 304

Über den Autor

Dr. Hao Yang, Process Chemist of Abbott Laboratories Global Pharmaceutical Research and DevelopmentDr. Yang, earned his undergraduate degree at East China University of Science and Technology in fine chemical engineering and his Ph.D. degree in organic chemistry from Emory University in 2009.