Therapeutic Oligonucleotides

Oligonucleotides are a promising new class of biomacromolecules for various therapeutic purposes to treat cancer, viral infections and inflammatory diseases. Antisense oligonucleotides against the cytomegalovirus and an aptamer to treat an ocular disease have already been approved by the regulatory authorities. A number of additional oligonucleotides including small interfering RNAs are currently in various phases of clinical development. Therapeutic Oligonucleotides provides a comprehensive overview of the development of oligonucleotides for therapeutic applications, touching on a number of different strategies with a special focus on the latest progress in the field of RNA interference. The book covers a wide range of topics: antisense oligonucleotides, small interfering and short hairpin RNAs, decoy and immune stimulatory oligonucleotides and aptamers as well as delivery of oligonucleotides. Written by experts in the field, both academic and industrial, Therapeutic Oligonucleotides provides a compelling overall update on current status of research and clinical development and will also serve as a valid resource for researchers and students as well as academics, consultants and scientists.