Synthesis of Novel Quinazolinone-Benzothiazole Hybrid Compounds
Some new amino substituted quinazoline compounds were synthesized and evaluated for their anticancer activity at National Cancer Institute (NCI), U.S.A. Among the synthesized nine compounds, two were selected for single high dose screening (10-5 M) in full 60 cell panel. Among the selected compounds, 2-benzamido-N-(benzo[d]thiazol-2-yl)benzamide 4 exhibited significant anticancer activity against non-small cell lung cancer NCI-H23, colon cancer HCT-15, CNS cancer SF-539, melanoma SK-MEL-5, ovarian cancer OVCAR-8, renal cancer ACHN, prostate cancer PC-3 and breast cancer MCF7 with inhibition rate of 97.82%, 99.67%, 99.21%, 90.75%, 99.21%, 99.3…
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Produktdetails
Weitere Autoren: Bhardwaj, Varun / Sharma, Poonam
- ISBN: 978-3-659-94189-4
- EAN: 9783659941894
- Produktnummer: 37574268
- Verlag: LAP Lambert Academic Publishing
- Sprache: Englisch
- Erscheinungsjahr: 2016
- Seitenangabe: 80 S.
- Masse: H22.0 cm x B15.0 cm x D0.5 cm 137 g
- Abbildungen: Paperback
- Gewicht: 137
Über den Autor
Mr. Vikrant Abbot is working as Assistant Professor at ISF College of Pharmacy, Moga, Punjab, India.
1 weiteres Werk von Vikrant Abbot:
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