Sticky triangles: New tools for experimental phasing of biological macromolecules
X-ray crystallography is the prime method for the elucidation ofthree-dimensional molecular structures. The determination of novelstructures is hampered by the crystallographic phase problem. Forbiological macromolecules experimental phasing is one technique tosolve this phase problem; it usually requires the incorporation ofheavy atoms in the protein crystal.In this thesis a new class of compounds was developed that combinesheavy atoms for experimental phasing with functional groups for interactionwith biological macromolecules. Three functional groupsinteract with protein residues and make the compounds sticky. Threehalogen atoms provide a…
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Produktdetails
- ISBN: 978-3-86955-729-8
- EAN: 9783869557298
- Produktnummer: 36224106
- Verlag: Cuvillier
- Sprache: Englisch
- Erscheinungsjahr: 2011
- Seitenangabe: 194 S.
- Masse: H21.0 cm x B14.8 cm x D1.0 cm 259 g
- Abbildungen: Paperback
- Gewicht: 259
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