Statistical Issues in the Design and Analysis of Clinical Trials
Chapters 1-4 concern statistical methods in designing and analyzing data for survival clinical trials, and predicting trial duration. Chapters 5-7 concern statistical methods in clinical trials with sequential parallel designs, which have been proposed for trials with high placebo response rates which can lead to a higher failure rate in drug development. Utilizing Box and Muller (1958), one of the most popular methods of generating standard normal random variable using two independent uniform (0, 1) deviates, a new method is proposed in Chapter 8 to combine two p-values from two disjoint samples for designing a trial with two stages.
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Produktdetails
- ISBN: 978-3-659-84554-3
- EAN: 9783659845543
- Produktnummer: 36361516
- Verlag: Sps
- Sprache: Englisch
- Erscheinungsjahr: 2017
- Seitenangabe: 248 S.
- Masse: H22.0 cm x B15.0 cm x D1.5 cm 387 g
- Abbildungen: Paperback
- Gewicht: 387
Über den Autor
Dr. Yanning Liu received a PhD in Statistical Science from Cornell University and is currently working as a statistical expert in a pharmaceutical company.
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