Solubility enhancement of poorly soluble drug by SLN
Solid lipid nanoparticles(SLNs) have been proposed as suitable colloidal carriers of drug with limited solubility. Ibuprofen SLNs prepared from mixture of Bees wax, Carnauba wax, and Ozokerite wax using Tween 80 as Surfactant. The characteristics of the SLNs with various lipids and surfactant composition were investigated. The mean particle size of drug loaded SLNs decreased upon mixing with Tween 80 as well as upon increasing total surfactant concentration. The zeta potential of these SLNs varied in the range of -1.58 to -24.4(mV), suggesting the presence of similar interface properties. High drug Entrapment efficiency of 90.0% revealed the…
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Produktdetails
Weitere Autoren: Patel, Arvind Kumar / Tiwari, Ruchi
- ISBN: 978-620-4-20246-4
- EAN: 9786204202464
- Produktnummer: 37682984
- Verlag: LAP Lambert Academic Publishing
- Sprache: Englisch
- Erscheinungsjahr: 2021
- Seitenangabe: 72 S.
- Masse: H22.0 cm x B15.0 cm x D0.4 cm 125 g
- Abbildungen: Paperback
- Gewicht: 125
Über den Autor
Dr. Gaurav Tiwari is an Associate Professor in Department of Pharmaceutics at the Pranveer Singh Institute of Technology, Kanpur. He completed his PhD from Jaipur National University, India. He has completed certification course onPatent Law for Engineers & Scientists from Department of Management, IIT, Madras.
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