Preparation and Solid-State Characterization of Leflunomide Polymorph
Tiwari et al. leflunomide polymorph along with its solubility assessment
Leflunomide is a drug with limited water solubility. It exhibits four polymorphic forms I,II,III,IV. In the present study, form II polymorph was formulated using form I. Form II polymorph readily dissolves in water than does form I. The crystals of form I and II polymorph were characterized by IR, DSC, XRPD. Comparison of solubility of form I and form II was done by UV Spectrophotometer. There was a significant increase in solubility of form II. Aqueous film-coated tablets of form I and form II were prepared using the same processing parameters and compared for the rate of dissolution. Form II tablets showed a significant improvement in terms…
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Produktdetails
Weitere Autoren: Tiwari, Ruchi / Bhati, Lokesh
- ISBN: 978-3-8484-1950-0
- EAN: 9783848419500
- Produktnummer: 37786665
- Verlag: LAP Lambert Academic Publishing
- Sprache: Englisch
- Erscheinungsjahr: 2012
- Seitenangabe: 132 S.
- Masse: H22.0 cm x B15.0 cm x D0.8 cm 215 g
- Abbildungen: Paperback
- Gewicht: 215
Über den Autor
Dr. Gaurav Tiwari (Assistant Professor) in the institute of Pharmacy, PSIT, Kanpur. He did his M.Pharm from Uttar Pradesh Technical University, Uttar Pradesh and Ph.D from Jaipur National University, Jaipur. He has five years of teaching experience and three year research experience, having more than 45 national and international publications.
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