PRF in Restorative dentistry and Endodontics

The principle goal of the contemporary endodontics is to get a low invasiveness and a high rate of clinical healing. Presently, regenerative surgery, has been widely introduced as a recent concept in dentistry. Regenerative medicine is the most fascinating field of biotechnology which is able to combine several aspects of medicine, cell and molecular biology, biomaterials and tissue engineering all aimed to regenerate, repair or replace tissues. The evolution of bioactive surgical additives, which are being utilized to modulate the inflammation and enhance the speed of healing process is one of the important challenges in clinical research.Very recently, a team of researchers has convincingly shown that lower centrifugation speeds and time resulted in higher leukocyte concentrations and release of growth factors. Ghanaati et al. demonstrated via histological processing of PRF scaffolds that at higher centrifugation speeds, the majority of leukocytes were found at the bottom of PRF scaffolds. By reducing centrifugation g-force, leukocytes were more evenly distributed throughout the PRF scaffolds.