Mucoadhesive system for Drotaverine Hydrochloride: A Novel approach
Buccal Delivery of Drotaverine Hydrochloride
In the present work an attempt has been made to have a faster antispasmodic action of Drotaverine HCl (DH) through combined approaches of enhancement of solubility and formulation (Buccal) approach. Enhancement of solubility was obtained through its complexation with CDs. DH-MßCD systems allowed a marked improvement of the initial drug water solubility. In particular, an increase of about 22 times was obtained for kneaded product. DSC, FTIR, and PXRD studies indicated that complexes can be formed by kneading method. The use of such drug-CD binary systems prepared by kneading method enabled preparation of directly compressible buccal tablets w…
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Produktdetails
Weitere Autoren: Kumari, Preeti / Verma, C P S
- ISBN: 978-620-2-52302-8
- EAN: 9786202523028
- Produktnummer: 37246747
- Verlag: LAP Lambert Academic Publishing
- Sprache: Englisch
- Erscheinungsjahr: 2020
- Seitenangabe: 100 S.
- Masse: H22.0 cm x B15.0 cm x D0.6 cm 167 g
- Abbildungen: Paperback
- Gewicht: 167
Über den Autor
Dr Vinay Pandit, Professor and Head, Dept of Pharmaceutics, Laureate Institute of Pharmacy, is an active researcher and working on novel drug delivery systems. He has a number of international and national publications. His current area of research includes Buccal and Nasal drug delivery systems. He has fetched a number of grants for his research.
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