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Rakesh Sharma

Molecular properties prediction and synthesis of oxadiazole analogues

Molecular properties prediction and synthesis of oxadiazole analogues as antimicrobial agents

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A series of 11 oxadiazole analogues were subjected to molecular properties prediction and drug likeness by Molinspiration and MolSoft software, lipophilicity and solubility parameters using ALOGPS 2.1 program. The compounds followed the Lipinski Rule of five were synthesized for antimicrobial screening as oral bioavailable drugs/leads. Further the structure of the synthesized compounds was confirmed by spectral analyses (IR, NMR and mass) and the compounds (4a-k) were evaluated for antibacterial and antifungal activities as per the standard protocol. N-(2-Methylphenyl)-5-(4-chlorophenyl)-1,3,4-oxadiazol-2-amine, 4c was found to have maximum a… Mehr

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Produktdetails

Weitere Autoren: Sharma, Piush / Ahsan, Mohamed Jawed
  • ISBN: 978-3-659-75863-8
  • EAN: 9783659758638
  • Produktnummer: 37437863
  • Verlag: LAP Lambert Academic Publishing
  • Sprache: Englisch
  • Erscheinungsjahr: 2015
  • Seitenangabe: 68 S.
  • Masse: H22.0 cm x B15.0 cm x D0.4 cm 119 g
  • Abbildungen: Paperback
  • Gewicht: 119

Über den Autor

Rakesh Sharma, a student of Maharishi Arvind College of Pharmacy (MACP), Jaipur, India has completed his M. Pharmacy (Pharmaceutical Chemistry) Project under the supervision of Dr. Piush Sharma, Professor and Principal, MACP, Jaipur, India. Dr Mohamed Jawed Ahsan, is working as Head, Department of Pharmaceutical Chemistry, MACP, Jaipur, India.

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