Long-lived Proteins in Human Aging and Disease

Discover the role that long-lived proteins play in the human aging process with this compelling new resource Long-Lived Proteins in Human Aging and Disease delivers a comprehensive treatment of the hypothesis that long-lived proteins are responsible for both age-related diseases and the aging process itself. Accomplished academic, researcher, and author Roger Truscott walks readers through a thorough review of the foundational and advanced topics necessary for understanding human aging. Together with other experts, he offers readers a description of the analytical methods used to study protein half-life and the accumulation of modifications, including several examples of long-lived proteins found in humans and other organisms. The book also presents an analysis of the molecular mechanisms of aging at the protein level and the most common side chain modifications, as well as a discussion of the consequences of protein aging on cellular and organ function. In addition to providing readers with a description of the impact of protein aging on several age-related diseases in humans, the authors also advance: A discussion of the ubiquity of long-lived proteins, contrasting with the common perception that protein turnover is rapid An analysis of the involvement of long-lived proteins in the aging process, including the many organs and tissues in which long-lived proteins are found An examination of the role that long-lived proteins play in the development of autoimmune diseases A treatment of age-related diseases, including an illustration of the role of age-related protein posttranslational modifications Perfect for biochemists, molecular biologists, cell biologists, and medicinal chemists, Long-Lived Proteins in Human Aging and Disease also belongs on the bookshelves of senior undergraduate and graduate students in any of these, or related, programs and courses. Finally, anyone with an interest in the role of long-lived proteins in the aging process will be well-served by reading this book.