Homology Modeling of Human NK-1 Receptor and Docking Study
Structure Based Drug Design
Neurokinin-1 (NK-1) receptor regulates many biological functions related to cancer, such as tumor cell proliferation, angiogenesis and migration of tumor cells for invasion and metastasis. The NK-1 receptor antagonists specifically inhibit tumor cell proliferation, migration of the tumor cells and show antiangiogenic effect. Therefore, the development of NK-1 antagonists for the treatment of cancer is of current interest. The 3D structure of NK-1 is not available from protein data bank. This hampers the design of selective NK-1 antagonists. This book describes the homology modeling of the human NK-1 receptor using multiple templates to provid…
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Produktdetails
Weitere Autoren: Kumar, Viney
- ISBN: 978-3-659-80420-5
- EAN: 9783659804205
- Produktnummer: 37402128
- Verlag: LAP Lambert Academic Publishing
- Sprache: Englisch
- Erscheinungsjahr: 2015
- Seitenangabe: 92 S.
- Masse: H22.0 cm x B15.0 cm x D0.6 cm 155 g
- Abbildungen: Paperback
- Gewicht: 155
Über den Autor
Manish Kumar Gupta (M. Pharm., PhD., Postdoc): Professor of Pharmacy, Lloyd Inst. of Mang. & Tech. Gr. Noida, India. His research work focuses on the ligand and structure based drug design, protein modeling and molecular dynamics simulation studies. He has published several research papers in peer-reviewed journals of ACS, Springer and Elsevier.
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