Hepatitis C virus infection
Predicting treatment response and the molecular mechanism of interferon resistance
Hepatitis C Virus (HCV) infects 170 million people worldwide. Current standard treatment with pegylated interferon alpha (IFNa) and ribavirin cures only 50% patients. Therefore, developing a prognostic tool that can be used to predict whether a given patient will respond to therapy is of great importance clinically. This book describes a novel predicting method based on a subset of 18 hepatic gene expression that predicts who will respond to therapy with an accuracy of 96%. A new ubiquitin-like signaling pathway (ISG15/USP18) was revealed to be involved in interferon resistance. Furthermore, preactivation of interferon signaling pathway leadi…
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Produktdetails
Weitere Autoren: McGilvray, Ian / Edwards, Aled
- ISBN: 978-3-659-24012-6
- EAN: 9783659240126
- Produktnummer: 37742204
- Verlag: LAP Lambert Academic Publishing
- Sprache: Englisch
- Erscheinungsjahr: 2012
- Seitenangabe: 248 S.
- Masse: H22.0 cm x B15.0 cm x D1.5 cm 387 g
- Abbildungen: Paperback
- Gewicht: 387
Über den Autor
Limin Chen,PhD: Studied molecualr genetics at University of Toronto. Professor at Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, P.R.China. Affiliated scientist at the Toronto General Research Institute, University of Toronto, Toronto,Canada.
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