HIC1 in Tumorigenesis
Novel Tumor Suppressor
A number of genetic alterations shown to be necessary for transformation of normal cell to a cancerous cell. While many of these changes are genetic, epigenetically mediated changes are being increasingly appreciated. Tumor Suppressor Genes reduce the tendency of a cell to undergo malignant transformation. P53 mutation is one of the molecular causes of neoplasm and considered as gene of conscience. It is found to be inactivated in 60-70% of cancer and in physiological condition the expression of p53 is low (1000-10000) in order to monitor the cellular integrity in mitotically growing cells and has short half life of 30 minutes due to rapid tu…
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Produktdetails
- ISBN: 978-3-639-76130-6
- EAN: 9783639761306
- Produktnummer: 36364980
- Verlag: Sps
- Sprache: Englisch
- Erscheinungsjahr: 2015
- Seitenangabe: 156 S.
- Masse: H22.0 cm x B15.0 cm x D0.9 cm 250 g
- Abbildungen: Paperback
- Gewicht: 250
Über den Autor
Sanjay received his PhD from AIIMS in 2011 (Brain Cancer Biochemistry). He moved to US and carried his research further in the field of Cancer and Stem cell therapy. He explored HIC1 role in tumorigenesis also cloned and expressed GC-rich HIC1. He discovered mechanism of stem cell survival in heart tissue during early and late phase of protection.
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