Female sex and ER-alpha modulate cardiac ischaemic remodeling
Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice
In this study, we present novel insights into mechanisms that account for the ERa-dependent myocardial protection against myocardial injury, with more beneficial effects in female hearts. Using a transgenic mouse model with a cardiomyocyte-specific ERa-overexpression (ERa-OE), we first demonstrated that this was associated with an increase of LVM at the basal level in both female and male mice. After MI, the cardiomyocyte-specific ERa-OE inhibited changes in LV-volumes and wall thickness only in female mice. These beneficial effects in female ERa-OE hearts were associated with increased angiogenesis and lymphangiogenesis, attenuated ventricul…
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Produktdetails
- ISBN: 978-3-8381-5128-1
- EAN: 9783838151281
- Produktnummer: 36372050
- Verlag: Südwestdeutscher Verlag für Hochschulschriften AG Co. KG
- Sprache: Englisch
- Erscheinungsjahr: 2017
- Seitenangabe: 92 S.
- Masse: H22.0 cm x B15.0 cm x D0.6 cm 155 g
- Abbildungen: Paperback
- Gewicht: 155
Über den Autor
Dr.med.Xiang Zhang,was born on the 12th of March 1982 in China, graduated from Harbin medical university(China)with B.Sc. and M.Sc.in Human medicine. Since 2009 he works as physician and lecturer at Harbin medical university. He obtained doctorate degree on the 30th of May 2015 from Charité - University Medicine Berlin,Germany.
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Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice
Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice
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